Oncogenic mRNA modification explained
نویسندگان
چکیده
منابع مشابه
Implications of widespread covalent modification of mRNA.
W hole transcriptome analysis reveals that one third of human and mouse genes express mRNAs containing methylated adenosines. Fat mass and obesity-associated (FTO) gene, a risk gene for obesity and metabolic abnormalities , demethylates the modified residues, suggesting a link between RNA methylation and disease. Vertebrate ribosomal RNA (rRNA), transfer RNA (tRNA), messenger RNAs (mRNAs) as we...
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Ferrocenyl carbodiimide (1) could be used for the direct labeling of synthetic RNA and expressed mRNA in vitro with the electrochemically active ferrocene moieties. These RNAs modified by 1 could be detected electrochemically coupled with a DNA probe-immobilized electrode. After hybridization of 1.1 Kb mRNA modified by 1 with the DNA probe-immobilized electrode, the peak charge observed by an O...
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N6-methyladenosine (m6A) is a reversible modification in mRNA and has been shown to regulate processing, translation and decay of mRNA. However, the roles of m6A modification in neuronal development are still not known. Here, we found that the m6A eraser FTO is enriched in axons and can be locally translated. Axon-specific inhibition of FTO by rhein, or compartmentalized siRNA knockdown of Fto ...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2018
ISSN: 1474-175X,1474-1768
DOI: 10.1038/s41568-018-0068-6